Answer

Can the EcoFlow RIVER 2 run ResMed AirSense 10 AutoSet with HumidAir humidifier?

Runs

Runs. Draw is 22 W, within the 300 W continuous output. Estimated runtime on AC: about 5.9 hr, counting about 15 W of inverter draw.

Medical safety notice: Will It Run? gives general power estimates only, not medical advice. Power draw varies by model, settings, pressure, humidifier and altitude. Before relying on any battery, power station, inverter or generator for a medical device, confirm approved power sources with the device manufacturer and your doctor or equipment supplier, and test your setup before an emergency. Never change prescribed settings to extend battery life. If your therapy is life-sustaining, keep the backup your supplier provides, register with your utility's medical-needs program, and have an evacuation plan. Run generators outdoors only, at least 20 ft from windows and doors, because of carbon monoxide risk. In an emergency, call 911.

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The comparison

EcoFlow RIVER 2ResMed AirSense 10 AutoSet with HumidAir humidifier
Continuous output / running draw300 W22 W
Capacity / average draw256 Wh nameplate, 218 Wh usable22 W
Runtime on AC5.9 hr (22 W + about 15 W inverter draw)
Nights on AC (8 hr)0.7
On DC, best caseNot modeled: ResMed's AirSense 10 guide says to turn humidity off on an external battery, and the Air10 DC converter's 13 A input is above a typical 10 A car port.
SourcesStation sourceAppliance source

How AC runtime is figured: usable Wh (nameplate × 0.85) ÷ (CPAP watts + about 15 W). The 15 W is the inverter's own draw just to stay on: BLUETTI counts about 15 W of self-consumption in its AC180 runtime formula, and an owner test measured about 17.5 W idle on a DELTA 3 Plus. Larger stations can idle higher, so test your own setup before you rely on it. DC figures skip the inverter and are a best case. Method and DC converter limits: CPAP power station guide.

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Questions

Can the EcoFlow RIVER 2 run ResMed AirSense 10 AutoSet with HumidAir humidifier?

Runs. Draw is 22 W, within the 300 W continuous output. Estimated runtime on AC: about 5.9 hr, counting about 15 W of inverter draw.

How was the runtime calculated?

On AC: 256 Wh × 0.85 = 218 Wh usable, divided by (22 W + about 15 W inverter draw) = 5.9 hr. Not modeled: ResMed's AirSense 10 guide says to turn humidity off on an external battery, and the Air10 DC converter's 13 A input is above a typical 10 A car port.

Where did the numbers come from?

US/CA comparison table: 256 Wh, 2 AC outlets at 300 W, X-Boost 600 W, 7.7 lb, LiFePO4, 3,000 cycles to 80%+. EcoFlow describes the 600 W figure as surge with X-Boost. Willrun treats it as a resistive boost, not motor-start capacity. The manual language for X-Boost says it suits heating devices. ResMed's therapy-device power table (ResMed Deutschland, Art.-Nr. 1018528/11) lists AirSense 10 AutoSet with HumidAir at 22 Wh during operation. Energy per hour equals average watts, so the average draw is 22 W. ResMed notes the values were measured in a lab and that a local meter can differ.